"she was like one who has discovered the sweetness of the twisted apples, she could not get her mind fixed again upon the round perfect fruit that is eaten in the city apartments..."See in text(Paper Pills)
The passage brings the simile of the apples back into the story. Dr. Reefy is equated with the "twisted" (unattractive) apples that are not picked but are actually the sweetest. "Round perfect fruit" can be interpreted as a metaphor for suitors who are attractive and appear to be desirable.
"It is delicious, like the twisted little apples that grow in the orchards of Winesburg..."See in text(Paper Pills)
Describes the story of Doctor Reefy with a simile comparing it to particular apples in Winesburg. The remainder of the paragraph describes the apples so that the comparison can be understood.